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Brand Name: Sovaldi

Generic/Chemical Name: Sofosbuvir 400mg

Sovaldi is an antiviral medicine used to treat Hepatitis C virus (HCV). It prevents the HCV cells to multiply in the body. Sovaldi is sometimes used in people who also have HIV, liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Sovaldi must be given in combination with other antiviral treatment medicine and should not be used alone. It is usually given in combination with ribavirin with or without peg interferon alfa.


The recommended dosage is to take 400mg once a day with or without food. The recommended regimen and treatment duration for SOVALDI combination therapy is provided in below Table.

Table 1 Recommended Regimens and Treatment Duration for SOVALDI Combination Therapy in HCV Mono-infected and HCV/HIV-1 Co-infected Patients






Patients with genotype 1 or 4 CHC

SOVALDI + peginterferon alfa* + ribavirin†

12 weeks


Patients with genotype 2 CHC

SOVALDI + ribavirin†

12 weeks


Patients with genotype 3 CHC

SOVALDI + ribavirin†

24 weeks




See peginterferon alfa prescribing information for dosing recommendation for patients with genotype 1 or 4 CHC.



Dose of ribavirin is weight-based (<75 kg = 1000 mg and ≥75 kg = 1200 mg). The daily dose of ribavirin is administered orally in two divided doses with food. Patients with renal impairment (CrCl ≤ 50 mL/min) require ribavirin dose reduction; refer to ribavirin prescribing information.




Ribavirin can cause birth defects or death in an unborn baby. Do not use sofosbuvir with ribavirin if you are pregnant, or if you are a man and your female sexual partner is pregnant. Use at least 2 effective forms of non- hormonal birth control while using these medicines together and for at least 6 months after treatment ends.


Active indgredient:  Sofosbuvir 400mg

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